The Human Immunome Project (HIP) is a small, dynamic, and ambitious global non-profit organization moving full-speed-ahead on our mission to accelerate the development of vaccines and immunotherapies against major global infectious diseases and cancers by decoding the human immune system. The immune system is at the core of our ability to adaptively respond to an ever changing and evolving world of disease threats. By decoding the human immune system, we can empower scientists to design more effective vaccines and immunotherapies for an almost limitless range of diseases -- potentially transforming public health in the 21st century.